I'd like to apply skill, cast (or bookcast) a spell, use an item and invoke Mindcraft with a single keypress.

I don't mind the design an implementation leaving it open. But it would be nice to keep settings per save (assuming very quick marks could be different for classes) and would be nice to load them for a new character from the previous one played (no matter if it has dead or is still alive).

It would be nice to even have macros allowing to configure any sequence of commands / key combination presses as a "quickmark" but if it's trickier to do I'm not asking for that.

As for the mouse UI such action could be placed in the HUD below the screen so that one can also invoke such an action with a single mouse click anytime.