There are certain prompts that are very easy to miss during gameplay that have a pretty big effect on things, and so should require specific keys to clear. The list should be kept small because a plethora would be annoying.

My non-exhaustive list is level ups and new corruptions.

Level ups should require a space or enter key to get through - there is specific precedent in the new talent selection screen, which you CANNOT press through by holding down any key, even with the toggle to accept any key instead of just space/enter. I can't count on two hands how many times I've fucked up skill ups in the early game by trying to gun through a mob (laptop mode keys).

The message about new corruptions should require the \ key to clear. These are also very easy to miss in the midst of combat in the endgame - it's particularly common to miss multiple corruptions on D:50.

Related issue with the corruption message: http://www.adom.de/forums/project.php?issueid=2046