It depends a lot on what I'm doing, I guess. I've played with all kinds of restrictions. I was recently playing a game without items (pretty hard), and I used to play a lot doomed, which usually meant no prayers (except to doom myself) and no crowning. If I'm doing a speedrun or something, OTOH pretty much everything is fair game.
For a casual game... anything that is boring and excessively repetitive, I probably don't bother with. Definitely no ID, or gremlin bombing or piety scum, probably no herbs except for what I can pick on the run. No precrowns or postcrowns. No Casino gold--I'll just rob it instead.
Hoping to win with every class, doomed. Archer, Barbarian, Bard, Beastfighter, Druid, Elementalist, Farmer, Fighter, Monk, and ULE Priest down.