When the RNG likes you

[The Cold Sailor]

Early game, what was the best luck any of you ever had? In the puppy cave, I managed to find both an artifact and a pool. A goblin on the bottom of the cave threw the emerald dagger at me, and the pool gave fate smiles, paralysis resistance, shock resistance, and a wish.

[gilesc]

Early game? Shirt of the Saints random drop in UD. Or perhaps the time a Chaos Servant around Khelevaster dropped a AoLS (not that remarkable, but it felt damned lucky).

Ever?
"You feel a surge of power. You feel truly excited." It's a giant vault.

Also, getting every stairs right on Mino Maze first try is a good feeling.

[Blasphemous]

Enter pyramid, a mummy on level 2 drops a glowing wand. 5 charges.