If I understand this correctly, Soirana is referring to a char in TWL, in league of awesomeness.
I played that char and hit a karmic lizard once. No prayers were used before.
As a result, praying at 1 HP gave the message of prayer unheard.
As far as I know, prayer priority in this case is HP -> then maybe curse removal.
Since prayer was unheard, the conclusion is that cursing blocks even HP prayers, which I would say is an excessive punishment, since dooming does the same.