I can say this particular idea is bad because
a) it will greatly increase game complexity (not the best in english, is there a word that fits more?) for classes like merchant or mindcrafter.
b) what's the difference with removing items on the floor in all dungeons?
c) stairhopping is not the only way to get items. You can just grind.
d) as said, this will affect ID games. Btw, Jelly, what's the "Weakest Link" game?
Removing item generation in stairs room sounds good though.