As we discussed on Steam earlier, a great new addition to ADoM would be NPC quests and factions.

For NPC quests, we could have random quests available by various NPC's.
Farmers might ask for logs to repair a house, or a new scythe because their broke, or ask you to go out and kill X number of wolves to protect their livestock.
A Merchant might ask you to find some rare item, or to track down a thief (random named monster) and bring back whatever they stole (which you might decide to keep if it's nice enough).
A Necromancer might ask you for a specific corpse, or to kill some Lawful NPC (random adventurer spawn) that's been chasing them.

Quest rewards could vary from gold and food and other minor items to skill training (Farmers teaching you Herbalism, a Thief teaching you Detect Traps, etc).
Possibly even earn you a companion (Farmer gives you his dog, a Necromancer might summon you a powerful minion).

As for Factions, they could be site based (Terinyo, Dwarftown, Outlaw Village, etc).
Doing quests for NPC's belonging to the faction would slowly increase your standing. Random NPC quests would give small amounts (increasing with difficulty of quest), while the current quests (like saving Yrrigs) would get you a more substantial amount.

Higher standing with a faction could earn you store discounts, maybe the occasional gift (farmer gives you a ration, blacksmith gives you a weapon or ingots). Could possibly even have faction specific NPC's for special training or specialty shops.