It's a pretty tough call. The bonuses are definitely good enough that it is probably worth considering. I have heard of people going through the last half of the game quite happily wearing the Crown of Science, and notice little ill effect, and the CoS is not so good as this.
I think a lot of it comes down to the fighter/caster problem. If you're a caster, you can probably use it to very good effect. Most of the worst problems with dooming all get dumped on melee classes--increased equipment damage, instakill paralysis, more critical hits, more punch through armor, more damage, miss more often, even higher spawn rate, for examples--all tend to be effects that you'll feel a lot more if you're fighting in melee rather than dual-wielding two shields on coward and bolting everything from a distance, and using teleport, darkness (if you're careful!) and invis to keep your distance and maintain good position play. Regeneration is pretty massive for casters, because it instantly tops up your HPcasting battery, so you can bolt with impunity.
For a caster (who actually casts, unlike most of mine, who use weapons far too often), I'd say it is definitely worthwhile in early game where the regeneration is too big to pass up. Gets less useful as game goes on as you find safer sources of regeneration, and your PV is topped up by other means, and remains a toss-up for most of the rest of the game. For melee... I wouldn't touch it unless you know exactly what you're doing. Doomed melee is very, very, risky.
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Even w/o dooming, I'm not sure it beats Preserver & BoW, which actually provide useful stat boosts & some +Luck. Sure [+13 +13] is amazing but it's not like we count Aylas Scarf as better than Preserver. w/o +Doom you'd certainly group it with them, but I guess it is a bit subjective.
Don't underestimate how good regeneration is. It's a crazy powerful intrinsic, and is definitely one of the main contributors to why those artifacts are so good. Holy scarf with regeneration would probably be better than Preserver for a lot of characters.
Last edited by JellySlayer; 11-19-2012 at 05:03 AM.
Hoping to win with every class, doomed. Archer, Barbarian, Bard, Beastfighter, Druid, Elementalist, Farmer, Fighter, Monk, and ULE Priest down.