With a little luck, I think Chaos Knights would make for a great speedrun. Here's my rough outline of how I think it could be done:
-Drake CK (for the tower boost and great To)
-Straight to CoC; knock Thrundarr off thing-ma-bobber; retrieve Moon Sickle (usually before Water Temple, but can be after it, of course) and do Water Temple. Moon Sickle is your source of on-demand healing. probably want to trade in SfB for PoCC--could be a good idea to lure him up to DT/level below DH:2 before wacking to death
-Pyramid, retrieve TP wand
-at this point, you are probably around level 15-17 and have around 8-10 corruptions [a nice +4-5 St/To/..Dx(?)]
-acquire means of crowning. probably sell-robbing, but you're only going to get 60-70k between barnabas and waldy. DFG is maybe another 5k. Probably going to have to sacrifice ankh or something.
-have extended means of invisibility [ring of invis?]; if not sip in DFG and pray
-next is ToEF. need to have First Aid in 90s, but this should be doable w/o any external healing excepting prayers. may need to sacrifice TP wand to get wand of digging to top level
-smack ACW around like a wet fish, especially if you have that beast armor
-dive, dive, dive.
It does require a little luck with corruption, but most of them are not game-enders. Even the stop healing corruption isn't bad on a Drake CK w/ Moon Sickle [on-demand healing, 1d(lvl) speed boost after level 12..only downside is -5 St, and +10 Wi is a pretty huge upside]. Hopefully Casino has good weapon since Moon Sickle is quite corrupting [of course, how you get moon sickle off is a good question since you don't have literacy and you can't use holy water....pray for disarmer, I guess]).
I currently have a Drake CK at 10500 turns who went through UD, retrieved moon sickle & did pyramid, so I think it's possible to do this pretty fast for people who know what they are doing
What do you guys think?