I'd rather see some rebalancing of certain things rather than outright removal... for example, there are a handful of skills (woodcrafting, haggling, metallurgy, survival, bridge building, law) that are pretty useless for general play in my experience. But I'd rather see useful applications for these skills, or have them replaced by ones that might be more useful. Similarly, a lot of talents are ridiculously underpowered and could probably be rebalanced. I think that the Sleep and Petrify conditions should be either removed or much more common. What's the point of having an intrinsic resistance to an attack that ONE rare monster in the game uses?
As far as locations go, I think that the maze should probably be cut by 2-3 floors in length. It would still be a good challenge, but it wouldn't feel as ridiculous as it currently does. Other than that, I can't think of anywhere else that I would want to lose. Gremlin Cave maybe? Bunny Master?