This is slightly spoily about the Ice Queen Domain, but not a lot.

I just had my third character who experienced a large shift toward chaotic in the IQD. This particular character:
-had been N-
-put on a blessed amulet of order (to start moving toward crowning eligibility) a bit before heading west
-picked up, from one square, a potion I'd potential willpower and about 3k gold. This made the ice creatures hostile, as expected, so he ball-spelled the 4-5 who came around him.
-he is now C, having moved from N- to C (at level 20) in about 6 turns or so.

I've had two prior characters (who reached IQD at L) who I suddenly discovered were chaotic, but that was farther along (in one case, in the frost giant caves; in the other, when I went back to the ice queen for quest reward ). Because of that, I wasn't sure exactly where the assignment drop had happened.

Have other people experienced this / do we know why? Is killing the ice-denizen victors from the battle somehow treated like killing beggars, even if they are hostile? Does pickling up those items somehow have a massively multiplied variant of the alignment effect of shoplifting?